One of the major problems facing creek dweller in oil producing communities is adaptation and health challenges. Depletion and pollution subject creek dwellers to harsh conditions in the phase of limited adaptation channels. While oil workers who move from Air Conditioned (AC) house to AC car and to AC office indulge in elaborate exercise to eliminate excess calories, creek dwellers appear malnourished with deep hunger which predisposes them to numerous health challenges. The paper highlighted the challenges and adaptation strategies of creek dwells in selected oil producing communities in Delta State. Explanation of core variables anchored on the theory of social exclusion. Focused group discussions, questionnaire and in-depth interviews were used to generate data. Total of 330 participants were sampled. Out of these, 11 interviews were granted. Thus, instrument triangulated both qualitative and quantitative techniques. Data was analyzed using percentages and thematic extraction of responses. Findings revealed that there is connectivity between oil exploration and the health challenges suffered by creek dwellers (96%). While the resource found within the region is a blessing to external bodies, it is a curse to creek dwellers. A total of 97.6% decay, high prevalence of communicable disease, poverty, illiteracy and hunger were predominant. They reported difficulty in making a living. Life chances are slim with oil exploration which worsened their condition. They harbor toxics, little illness knocks them down and in most cases this terminates their life. The consciousness of exploitation instigated some attacks which disrupted normal activities. Unfortunately, the effects of this attacks fall back on the local dwellers and not the target group.