The effects of chronic consumption of zobo drinks commonly used as red coloured soft drinks on the kidney of adult wistar rats were investigated. The rats of both sexes (n=20), with an average weight of 200g were randomly assigned into test (n=10) and control (n=10) groups. The rats in the test group was given zobo drinks liberally on a daily basis for thirty days while the control group received water liberally for the same period and through the same route. The rats were fed with grower’s mash obtained from Edo Feeds and Flour Mill Limited, Ewu, Edo state, Nigeria. The rats were sacrificed by cervical dislocation method on the thirty-first day of the experiment and the kidney was carefully dissected out, dried, weighed, and quickly fixed in 10% formal saline for further routine histological study. The findings indicated that there was a significant (P < 0.05) decrease in weights (g) and increase in relative weights (%) of the test kidneys (right and left) as compared to the control group. The microanatomy (H & E) indicated that the kidney in the test group showed some level of distortion and disruption of the cytoarchitecture of the renal cortical structure, diffuse glomerulonephritis with some congestion of blood and an enlarged Bowman’s space as compared to the control group. Chronic consumption of zobo drinks may therefore have an adverse effect on the kidney of adult wistar rats. It is recommended that further studies aimed at corroborating these observations be carried out.