NIGERIAN JOURNAL OF SCIENCE AND ENVIRONMENT
Journal of the Faculties of Science and Agriculture, Delta State University, Abraka, Nigeria
ISSN: 1119-9008
DOI: 10.5987/UJ-NJSE
Email: njse@universityjournals.org
ANTIOXIDANT EFFECT OF AQUEOUS SEED EXTRACT OF AFRAMOMUM SCEPTRUM (KSCHUM) ON BRAIN AND KIDNEY OF MALARIA INFESTED MICE
DOI: 10.5987/UJ-NJSE.16.065.1 | Article Number: 74D11016 | Vol.14 (1) - July 2016
Author: Anigboro Akpovwehwee A
Keywords: Kidney, Malaria, oxidative stress, Aframomum sceptrum, antioxidants, brain
The present study investigated the antioxidant effect of aqueous seed extract of Aframomum sceptrum against oxidative stress induced in Plasmodium berghei infected mice. Adult-albino mice (male), weighing 15-25 g, were inoculated intraperitorically with 0.1 ml parasitized blood suspension. A. sceptrum extract was orally administered at different dosages (250 and 350 mg/kgb.wt), daily to both normal and malaria induced mice for a period of 4 days. There was increase in uric acid level and decrease in albumin, respectively, in brain and kidney in malaria mice compared to normal control. After treating with A. sceptrum, a significant (p<0.05) decrease and increase in uric acid and albumin levels, respectively, in the parasitized mice’s brain and kidney were observed compared to the parasitized control. The results suggest that A. sceptrum extract may contribute to the prevention of oxidative damage caused by malaria.
Abudulelah, A.A.A, and Zainal-Abidin, A.A.H. (2007) Invivo antimalarial test of Nigella sativa (Black seed) different extract. AM. J. Phamarcol. Toxicol. 2(2): 46-50.
Nergiz, C. and Otless, S. (1993). Chemical composition of Nigella sativa L. seeds. Food Chemical. 48: 259-261.
Levander, O.A., Fontela, R. Morris, V.C. and Ager, A.L. (1995). Protection against murine cerebral malaria by dietary-induced oxidative stress. J. Parasitol. 81: 99-103.
Adegoke, G.O. and Skura B.J. (1994), Nutritional Profile and antimicrobial spectrum of spice Aframomum daniefli K, Schum. Plant food Hum. Nutri, 45:175-182.
Aviran, M. (2000). Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases. Free Radic Res 33:585-897.
Caraway, W.T. (1963). Quantitative determination of uric acid. Clin. Chem.. 4:29-243.
Doumas, B.T., Waston, W. A. and Brigy, A.C. (1971). Abumin standard and the measurement of albumin with bromocresol green. Clin. Chem. 31:87-91,
Elesha, S.O, Adepoju FB, and banjo AA (1993). Rising incidence of Cerebral malaria in Lagos Nigeria: a postmortem study. E Afr. Med .J. 70:302-306.
Floyd, R.A. and Carney, J.M (1992) Free radical damage to protein and DNA: Mechanisms involved. Ann. Neurol. 32:22-27.
Gora, D. Sandhya, M. and Praveen,S. (2006). Oxidative stress, Tocopherol, ascorbic acid and Reduced Glutathione status in schzophnics. Ind. J. Chem. Biochem. 21(2):34-38.
Nelson, D.L. and Cox, M.M. (2005). Lehninger Principle of Biochemistry. 4th Ed. W.H. freeman and Company. New York. pp. 873-874.
Halliwell, B. (1994). Antioxidants and human disease: A general introduction. Hutr. Reviews 55:522-544.
Hayden, M. R., Tyagi, S.C., and Hepper, F.N. (2004). Uric acid and peroxidant at elevated level. Nutri Metabol 1(1): 10-4.
Hunt, N.H and Stocker, R. (1990). Oxidative stress and the radox status of malaria infected erythrocytes. Blood Cells 16:499-526.
Iyawe, H.O.T. and Onigbide, A.O. (2009). Impact of Plasmodium berghei and chloroqunte on Haematological and Antioxidant indices in mice. Asian j.h Biochem 4(1): 30-35.
Jackson, J.H, and Cochran, C.G, (1988). Leukocyte induce tissue injury. Hematol. Oncol. Clin North Am. 2:317-334.
Janse, C.J., Ramesar, J and Waters, A.P. (2006). High-efficiency. Transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite. Nature. 1:346-356.
Neil, A.l. and Hunt, N.H. (1992). Pathology of fatal and resolving Plasmodium berghei cerebral malaria in mice. parasitology. 105:165-173.
Roman, G.C. (1991). Cerebral Malaria: The unsolved riddle. J. Neurol Sci. 101:1-6.
Shamay, A. (2005). Albumin concentration in the cerebrospinal fluid (CSF). Lymphology. 37:65-72.
Shiff, C. (2002). Integrated approach to malaria control. Clin. Microbiol. Rev. 15:278-293.
Thumwood, C.M., Hunt, N.H., Cowden, W.B and Clark, L.A. (1989). Antioxidants can prevent cerebral malaria in Plasmodium berghei Infected mice. Br. J. Exp. Pattol. 70:293-303.
WHO. (2000). Severe falciparum malaria trans. R. Soc Trop Med. Hyg. 94(suppl 1) 1-90