Journal of the Faculties of Science and Agriculture, Delta State University, Abraka, Nigeria

ISSN: 1119-9008
DOI: 10.5987/UJ-NJSE


DOI: 10.5987/UJ-NJSE.17.126.1   |   Article Number: 5E1DE4171   |   Vol.15 (1) - November 2017

Author:  Anigboro Akpovwehwee A.

Keywords: Kidney, Malaria, Aframomum sceptrum, lipid profile, glutathione, malondialdehyde

The effect of aqueous extract of Aframomum sceptrum (spice) on the kidney of mice induced with malaria was assessed in this study. Six groups of six mice each were used: normal control, parasite control, normal + 250 mg of spice, parasite + 250 mg of spice, parasite+350 mg of spice and normal+350 mg of spice. After four days of treatment with aqueous extract of A. sceptrum, the mice were sacrificed and the kidneys collected to determine the levels of some biomarkers. The results revealed that the parasitized mice had a significant (p<0.05) increase in triglyceride (TG), malondialdehyde (MDA), low-density lipoprotein (LDL)-cholesterol and a significant (p<0.05) decrease in high-density lipoprotein (HDL)-cholesterol. These parameters were, however, significantly decreased when parasitized mice were treated with the aqueous extract of A. sceptrum. However, no significant (p>0.05) alteration was observed in kidney level of reduced glutathione (GSH). It can be inferred that the antioxidants and bioactive metabolites of A. sceptrum are responsible for the observed change. Thus, A. sceptrum can play a crucial function in the management of malaria.

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